LE significantly enhanced the therapeutic efficacy of TAE in a rat model of HCC compared to PE. These results highlight the potential of LE's to improve ischemia and necrosis, thereby offering a promising option for improving the efficacy of embolization for HCC treatment. Gurevich, Alexey, et al. Journal of Vascular and Interventional Radiology (2024).

Animal models that recapitulate human disease are greatly needed. Leveraging xenograft tumors derived from patients with advanced HCCs and a commercially available immunodeficient mouse strain that expresses human GM-CSF and IL-3, we demonstrate a novel but accessible approach for modeling the HCC tumor microenvironment. Kelley, et al. JHEP Reports (2024): 101264.

GPC3-specific optical imaging enabled the detection of the GPC3+ HCC cells and noninvasive monitoring of tumor response to adoptive immunotherapy. The integrated development of a targeted therapeutic and molecular imaging probe provides a promising paradigm for the development of cancer theranostics. Habibollahi, Peiman, et al. Molecular cancer therapeutics 23.12 (2024): 1815-1826.